The Atlantic Magazine has an item titled U.S. Women Are Dying Younger Than Their Mothers, and No One Knows Why, by Grace Wyler, October 7, 2013, which has this specific demographic note:

Other researchers have pointed out the correlation between education rates and declining female health outcomes. The most shocking study, published in August 2012 by the journal Health Affairs, found that life expectancy for white female high-school dropouts has fallen dramatically over the past 18 years. These women are now expected to die five years earlier than the generation before them—a radical decline that is virtually unheard of in the world of modern medicine. In fact, the only parallel is the spike in Russian male mortality after the fall of the Soviet Union, which has primarily been attributed to rising alcohol consumption and accidental death rates.

I can't provide an explanation for the life expectancy, but this item lower down is something I can explain

In May, Jennifer Karas Montez, a social demographer who studies health inequalities, co-authored a study that was the first to investigate how quality of life might be playing a role in the early deaths of female high-school dropouts. Montez found that while smoking accounts for half of the decline in life expectancy among these women, whether or not a woman has a job is equally significant. “Women without a high-school degree have not made inroads in the labor force, especially in post-recession America,” Montez said in an interview. In fact, only one-third of women without a high-school diploma are employed, compared to half of their male counterparts, and nearly three-quarters of better-educated women. When they are employed, Montez said, it is usually in low-wage jobs that offer no benefits or flexibility. Smoking and other destructive behaviors, she added, may just be symptoms of the heightened stress and loneliness experienced by women who don’t graduate from high school.

“Life is different for women without a high-school degree than it was a few decades ago, and in most cases it’s a lot worse,” she said. “It’s really just a perfect storm.” [Emphasis added]

For white low-wage employees, the difference between America "a few decades ago" and today is explained by mass immigration. Those women would have more jobs and better jobs if it weren't for millions and millions on low-wage immigrants.